Minutiae of my every day since 2004.
The upright man is no adorer of public opinion. (location 45)
This is the question the upright man propounds to himself, "Will this bring glory to God?" He labors still to bring in some revenues into the treasury of heaven. He prefers the glory of God before whatever comes in competition with, or stands in opposition against it. If life is laid in one balance, and God's glory in the other--the glory of God outweighs. (loc. 86)
An upright Christian, though he fails in every duty, yet he makes conscience of every duty. (loc. 110)
The upright Christian does not whirl about, or sinfully prostitute himself to the lusts and desires of men. (loc. 121)
True grace ennobles the heart, dilates the affections, and carries out a man beyond the sphere of his private concernments, making him mind the church's condition as his own. (loc. 175)
He has peace with his conscience. 1 John 5:10, "He who believes has the witness in himself." his end must needs be peace--who has a smiling God, and a smiling conscience. Augustine calls it, "the paradise of a good conscience." A godly man is in this paradise before he dies.

At the behest of his soon-to-be wife, Adrian Tomine set out to create a wedding favor for their guests that would be funnier and more personal than the typical chocolate bars and picture frames. What started out as a simple illustrated card soon grew into a full-fledged comic book: a collection of short strips chronicling the often absurd process of getting married. A loose, cartoony departure from Tomine’s previous work, Scenes from an Impending Marriage is a sweet-natured, laugh out-loud skewering of the modern marriage process, including hiring a DJ, location scouting, trips to the salon, suit fittings, dance lessons, registering for gifts, and managing familial demands. The most personal and autobiographical work of Tomine’s career, Scenes from an Impending Marriage is a charming, delightful token of love.

This project seeks to understand G protein inhibition in the treatment of uveal melanoma and other Gq-related diseases. The heterotrimeric G proteins are molecular switches regulate biological functions like sight, smell, and memory. This pivotal role makes G proteins essential players in physiology and pathophysiology. However, when G proteins mutate, they result in a variety of diseases from cancer to heart disease. For example, a single mutation in the Gq protein is known to cause uveal melanoma, a cancer in the iris of our eyes that remains largely untreatable short of removing the eye. This is due to an over-active Gq protein. Thus, targeting over-active Gq mutants presents a unique opportunity to treat disease.
Natural product chemistry offers the chance to identify treatments against these difficult to treat targets. A peptide found in Christmas berries, YM-254890 (YM) binds and inhibits Gq, preventing the over-active from resulting cancers. Previous results suggest that YM is even useful in cellular and animal models. However, both the mechanism of Gq inhibition as well as how to optimize YM further (for simplicity, potency, or specificity) remain unknown. This project simulates the heterotrimeric Gq protein bound to YM, to understand its mechanism. Project 16446 simulates the Gq protein by itself, which will help us understand its behavior in the cell.





"Never mind that I knew relatively little about other sciences, this first puppy love seemed life-changing."
"In contrast, my encounter with biology left me completely cold."
"My most awkward moment came when an older woman, suffering from severe unstable angina, asked me what I believed." Dr. Collins was not really sure.
"I had started this journey of intellectual exploration to confirm my atheism. That now lay in ruins as the argument from the Moral Law (and many other issues) forced me to admit the plausibility of the God hypothesis. Agnosticism, which seemed like a safe second-place haven, now loomed like the great cop-out it often is. Faith in God now seemed more rational that disbelief.
... For me the experience of sequencing the human genome, and uncovering this most remarkable of texts, was both a stunning achievement and an occasion for worship.
Many will be puzzled by these statements, assuming that a rigorous scientist could not also be a serious believer in a transcendent God. This book aims to dispel that notion, by arguing that belief in God can be an entirely rational choice, and that the principles of faith are, in fact, complementary with the principles of science.
So here is the central question of this book: In this modern era of cosmology, evolution, and the human genome, is there still a possibility of a richly satisfying harmony between the scientific and spiritual worldviews? I answer with a resounding yes. In my view, there is no conflict in being a rigorous scientist and a person who believes in a God who takes a personal interest in each of us. Science's domain is to explore nature. God's domain is in the spiritual world, a realm not possible to explore with the tools and language of science. It must be examined with the heart, the mind, and the soul--and the mind must find a way to embrace both realms.
I will argue that these perspectives not only can coexist within one person, but can do so in a fashion that enriches and enlightens the human experience.
What’s the most profound thing you’ve each learned from each other?
KG: Oh gosh. Is this an overnight? For me, there is no way of feeling the depth of staying together for 40 years. You share it, you’ve created a common history. You see a lot of marriages you don’t want to be like, and you have the illusion you’ll never cause each other pain, and then you kill each other. But there’s something in getting through all that.
I remember Henry Fonda was watching him in Evita, and at the intermission, I happened to be sitting in front of him, and I heard him say, “This couldn’t be this Pad-inkin fellow’s first musical!”
And I went, “Excuse me, Mr. Fonda, it is.” And he turned and looked at me and said, “Oh, are you related?” And that’s when it really struck me. I said, “About to be.” We’re related. We’re kin and we made a family.
We talk a lot about being stunned about being older. Some days it’s really shocking. But even when it’s shocking, I see him as the person I first met. I see that person in him now. So I get more of him. I get the gorgeous young guy and the gorgeous old guy.
What about you, Mandy?
MP: I never experienced unconditional love until I met her. [He tears up.]
I love this conversation.
KG: I do, too.

The joy of a doctor who had recovered from COVID-19 was cut short after she again tested positive for the virus a few days after she left the hospital.
According to Ivan Mayrina's report on "24 Oras," Dr. Karen Abat-Senen could not hide her joy and even posted a video of her singing on July 3, the day she went home after a month of confinement at the Philippine General Hospital.
However, a few day later, the doctor experienced worse symptoms.

Please include our hospital Neonatologist in your prayers. Dr. Senen is a dedicated and passionate pediatrician with a heart of service for the Filipino babies. She is the wife of Dr Jerome Senen, (also a pediatrician) and mother of two. Both are UP College of Medicine alumni.
[Reposting] Help and prayers for Dra. Karen Abat-Senen.
This is a call for help. Dra. Karen's condition has gone from bad to worse. Her lungs cannot take in oxygen because of the inflammation caused by the infection. They placed her in prone position to help improve oxygen intake, however, her condition still regressed. She, right now, is in a very bad state. An option offered by the her physicians is to have her plugged to an ECMO machine. The problem is, UP PGH does not have an ECMO machine. They will try to make arrangements to borrow one for us to rent which comes at a steep price. Initial cashout needed is 750k Php and daily rate afterwards is 20k Php. Now, once she is placed in ECMO support, she would need lots of blood, O+ blood, not necessarily from COVID 19 survivors. For blood donations, they may walk-in at the Blood Donor Center at the back of Ward 3 or they can also call 0947-4882817 to coordinate. Please let the blood be earmarked for KATHLYNNE ANNE A. SENEN.
FOR BLOOD DONATIONS: Click on this link: http://tinyurl.com/pghscreen.

With the two criteria of edification and entertainment or enjoyment serving as a platform, here are five novels that I feel comfortable recommending to Christian readers.
Great Expectations by Charles Dickens
The Scarlet Letter by Nathaniel Hawthorne
The Death of Ivan Ilyich by Leo Tolstoy
The Hammer of God by Bo Giertz
The Stranger by Albert Camus
Does God care about what novels we read? He does. He expects us to exercise good stewardship of our time, which includes a realization that leisure is a Christian calling in the sense that God commands it.
With that as a starting premise, what constitutes a good use of our leisure time? Growth. Leisure can edify as it refreshes.

Unto the grave, what shall we sing?
“Christ, he lives; Christ, he lives!”
And what reward will heaven bring?
Everlasting life with him.
There we will rise to meet the Lord,
Then sin and death will be destroyed,
And we will feast in endless joy,
When Christ is ours forevermore.
"What is your only comfort in life and in death?” For centuries, believers have learned the Christian faith beginning with that question. It’s the first article in the Heidelberg Catechism of 1563. Why start there? Because death is our common fate. Unless Jesus returns first, we will all die. To find comfort in life, we must know how we can face death. Hope comes only in trusting the one who died to take the curse of death and who crushed the power of death by his resurrection. “Christ has been raised from the dead” (1 Cor 15:20). That is the only statement that can transform how we live each day and how we prepare for our earthly life to end.

The Spirit of the Beehive is set just after the end of the Spanish Civil War, and the house is paralyzed with sorrow, or fear, or both. Franco the dictator was still alive when the film came out, but maybe it was too enigmatic to incur the ire of the censors. Or else the censors counted on the audience not getting it. Today it is hailed as a masterpiece, its eerie quiet the appropriate soundtrack for a nation traumatized by war.



Crafted by Bottled Brain, copyright 2004