Sunday, September 16, 2018

Steroids decrease efficacy of PD-1/PD-L1 inhibitors in NSCLC

Dr. Matthew Stenger, via The ASCO Post:

In a study reported in the Journal of Clinical Oncology, Arbour et al found that baseline treatment with corticosteroids was associated with poorer efficacy of programmed cell death protein 1 (PD-1) or programmed death cell ligand 1 (PD-L1) inhibitors in patients with non–small cell lung cancer (NSCLC).

Furthermore,

The investigators concluded, “Baseline corticosteroid use of ≥ 10 mg of prednisone equivalent was associated with poorer outcome in patients with non–small cell lung cancer who were treated with [PD-1/PD-L1] blockade.”

Baseline corticosteroids were associated with decreased overall response rate, progression-free survival, and overall survival with PD-(L)1 blockade.

What's the clinical impact for oncologists? Must we then avoid corticosteroids entirely? The authors recommend its "prudent" use.

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