Nothing wears a Christian down more than the habit of prayerlessness. I say it is a habit because it develops gradually, and once established, it is difficult to erase. It is never abrupt when it takes it toll; there are always obvious signs that precede it--a disinterest in the meditation of Scripture, a lack of enthusiasm in fellowshipping with other Christians, a vague idea of the Cross and what it stands for, and an ongoing emergence of past sins in one's lifestyle. The appropriate response would be to come to God in prayer. Ask Him to search your hearts. "If there is any wicked way in me, lead me in the path everlasting."