Skip to main content

Steroids decrease efficacy of PD-1/PD-L1 inhibitors in NSCLC

Dr. Matthew Stenger, via The ASCO Post:

In a study reported in the Journal of Clinical Oncology, Arbour et al found that baseline treatment with corticosteroids was associated with poorer efficacy of programmed cell death protein 1 (PD-1) or programmed death cell ligand 1 (PD-L1) inhibitors in patients with non–small cell lung cancer (NSCLC).

Furthermore,

The investigators concluded, “Baseline corticosteroid use of ≥ 10 mg of prednisone equivalent was associated with poorer outcome in patients with non–small cell lung cancer who were treated with [PD-1/PD-L1] blockade.”

Baseline corticosteroids were associated with decreased overall response rate, progression-free survival, and overall survival with PD-(L)1 blockade.

What's the clinical impact for oncologists? Must we then avoid corticosteroids entirely? The authors recommend its "prudent" use.

Comments

Popular posts from this blog

Tarps and COVID-19

Saw this in my feed. So Pinoy in many respects:  the graduation photo the tarp with three fonts: Monotype Corsiva ("Congratulations"), Arial (the girl's name), and the serif below the papaya tree the use of the middle name the color scheme (pink in white) the iconic Philippine countryside It's the first time I'm hearing about Zarraga, some 16 km north of Iloilo City. Seems like a charming place to visit. Also COVID-free. 

Week 9, 2012: Aboard the MV Logos Hope

I met old friends from college last Saturday. We had breakfast at an old restaurant along Ongpin Street called Saludo's. Some of us went to Logos Hope, a ship with lots of books inside it—some 5000 titles, we were told. The sun was hot, in a cancerous, melanoma-inducing kind of way. Summer is just right around the corner. Took us a while to get inside the ship. I thought this view of Manila's skyline from one of the windows was amazing. We saw what we came for: books. They were sold in "units" that had a corresponding peso conversion. The books sold cheaply, so I got David Copperfield by Charles Dickens for 150 units (Php 150). I plan to read at least one Dickens novel this year, 2012 being his 200th birthday. (I'm ashamed to admit I haven't read a single novel of his, ever). I saw Nancy Drew, Hardy Boys, classics, modern fiction, modern Christian literature, biographies, medical and nursing textbooks, and children's books. Visit